Reid Hoffman, the co-founder of LinkedIn and a prominent figure in the tech industry, has announced his departure from Microsoft’s board of directors after nearly a decade on the board. The move was disclosed in a regulatory filing by Microsoft on Thursday, marking the end of Hoffman’s tenure as a board member at the tech giant.
Shifting Focus to AI Drug Discovery Startup
Hoffman cited his desire to enter “founder mode” as the primary reason for stepping away from Microsoft. He plans to dedicate his efforts to Manus, an AI-powered drug discovery startup that he founded. The company is focused on leveraging artificial intelligence to accelerate the development of new therapeutics, a field that has seen growing interest and investment in recent years.
Manus represents a strategic pivot for Hoffman, who has long been involved in ventures at the intersection of technology and innovation. His decision to leave Microsoft’s board underscores a broader trend among seasoned executives to pursue entrepreneurial opportunities in emerging sectors, particularly those with transformative potential like AI-driven healthcare.
Legacy at Microsoft and Future Outlook
Hoffman joined Microsoft’s board in 2016, shortly after the company acquired LinkedIn for $26.2 billion. His role was instrumental in guiding Microsoft’s strategy during a pivotal period of growth and digital transformation. His departure signals a shift in his professional focus, moving away from large-scale corporate governance to hands-on startup leadership.
With Manus, Hoffman is betting on the convergence of AI and biotechnology—a space that is rapidly evolving and attracting significant capital. The startup’s mission to use machine learning for drug discovery aligns with global trends in precision medicine and personalized healthcare, positioning it well for future growth.
Conclusion
As Hoffman transitions into his new role, his departure from Microsoft’s board marks the end of an era and the beginning of a new chapter in his entrepreneurial journey. His move to lead Manus reflects a growing interest in applying AI to solve complex challenges in healthcare, a sector that continues to evolve with the integration of advanced technologies.



